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XEMIS2 Liquid Xenon Compton Camera for Small Animal 3γ Medical Imaging: Scintillation Light Measurement

Yuwei Zhu 1 Stephane Acounis 1 Nicolas Beaupere 1 Jean-Luc Beney 1 Julien Bert Stephane Bouvier 1 Clotilde Canot 1 Thomas Carlier Michel Cherel 2 Jean-Pierre Cussonneau 1 S. Diglio 1 Debora Giovagnoli Jérôme Idier 3 Francoise Kraeber-Bodere Patrick Le Ray 1 Frédéric Lefevre 1 Julien Masbou 1 Eric Morteau 1 Jean-Sebastien Stutzmann 1 Dimitris Visvikis Yajing Xing 1 Dominique Thers 1
1 SUBATECH - Laboratoire de physique subatomique et des technologies associées
2 UN - Université de Nantes
3 LS2N - Laboratoire des Sciences du Numérique de Nantes
Abstract : An innovative XEnon Medical Imaging System, named XEMIS2, consisting of a liquid xenon (LXe) Compton camera, is developed to image small animal with 3γ imaging technique. The main objective of XEMIS2 involves the 3D localization of a radiopharmaceutical labeled with a specific radionuclide 44 Sc and the lessening of the administered radiotracer activity while preserving the image quality in oncology diagnosis. XEMIS2 is a monolithic single-phase detector with a large axial Field Of View (FOV), handling up to nearly 200 kg of ultra-high-purity liquid xenon. The XEMIS2 facility has been successfully conceived and developed at the SUBATECH laboratory. In XEMIS2, the scintillation signals provide the γ-rays interaction time. Furthermore, it is possible to pre-localize the γ-rays interactions spatially and then achieve the virtual fiducialization of the active volume by matching the scintillation signals with the ionization signals. In order to measure scintillation light, we distribute a set of PhotoMultiplier Tubes (PMTs) around the surface of the active area. Besides, a self-triggered scintillation light detection chain has been specially developed for XEMIS2 to carry out continuous data taking with negligible electronics dead-time. It is currently calibrated in the prototype XEMIS1. The calibration results indicate that the dedicated detection chain has a good performance in scintillation light measurement. XEMIS2 is recently under construction in a small animal medical imaging center CIMA, for further preclinical studies. I. INTRODUCTION OR the past few decades, nuclear medical imaging has extended from organ imaging for tumor localization of a variety of diseases and proven remarkable value in oncology Manuscript received
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https://hal-imt-atlantique.archives-ouvertes.fr/hal-03044142
Contributor : Sara Diglio <>
Submitted on : Tuesday, December 15, 2020 - 10:24:48 AM
Last modification on : Wednesday, January 27, 2021 - 9:33:13 AM
Long-term archiving on: : Tuesday, March 16, 2021 - 6:10:25 PM

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IMT-ATLANTIQUE | SUBATECH | IN2P3 | UNIV-NANTES | CNRS | INSTITUT-TELECOM | LS2N | UNAM | EC-NANTES | SUBATECH-XENON | SUBATECH-SERVICES-TECHNIQUES | LS2N-SIMS

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Yuwei Zhu, Stephane Acounis, Nicolas Beaupere, Jean-Luc Beney, Julien Bert, et al.. XEMIS2 Liquid Xenon Compton Camera for Small Animal 3γ Medical Imaging: Scintillation Light Measurement. 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Oct 2019, Manchester, United Kingdom. pp.1-4, ⟨10.1109/NSS/MIC42101.2019.9059638⟩. ⟨hal-03044142⟩

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