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Direct Measurement of Ionization Charges in Single-phase Liquid Xenon Compton Telescope for 3γ Medical Imaging

Yajing Xing 1 Mounir Abaline 2 Stephane Acounis 1 Nicolas Beaupere 2 Jean-Luc Beney 1 Julien Bert 1 Stephane Bouvier 1 Clotilde Canot 1 Thomas Carlier 3 Herve Chanal 2 Michel Cherel 3 Jean-Pierre Cussonneau 1 Sara Diglio 1 Debora Giovagnoli Jérôme Idier 4 Francoise Kraeber-Bodere 3 Patrick Le Ray 1 Frédéric Lefevre 1 Samuel Manen 2 Julien Masbou 1 Eric Morteau 1 Nicolas Pillet 1 Didier Roy 1 Laurent Royer 2 Jean-Sebastien Stutzmann 1 Richard Vandaele 2 Dimitris Visvikis Yuwei Zhu 1 Dominique Thers 1
1 SUBATECH - Laboratoire de physique subatomique et des technologies associées
2 LPC - Laboratoire de Physique de Clermont
3 UN - Université de Nantes
4 LS2N - Laboratoire des Sciences du Numérique de Nantes
Abstract : We report the study of direct measurement of ionization charges in an innovative liquid xenon Compton camera of small animal imaging, named XEMIS2. It was combined with a novel 3γ medical imaging modality, showing a "TOF-like" PET performance, targeted to reduce the administered activity diametrically while preserving the image quality in oncology diagnosis. For the Compton cones reconstruction, the sequential low energy electronic recoils from Compton scattering of third γray (∼ 1 MeV) are measured directly from ionization signals under a high electric field of 2 kV/cm. The Geant4/NEST simulations studies reveal that the intrinsic energy and spatial resolutions of charges carriers measuring in liquid xenon are dominated respectively by the electron-ion recombination and the abstruse trajectory of recoil electrons. Besides, a novel ASIC front-end electronic, XTRACT, and data acquisition chain were developed, dedicated to optimizing the accuracy and efficiency of ionization signals measurement in XEMIS2. It allows a continuous read-out with ultra-low charges threshold and negligible deadtime per individual channel. The performing characteristics were calibrated in the prototype XEMIS1 under the XEMIS2 operation condition, showing a good homogeneous charge linearity response. Meanwhile, the data processing and analysis were developed, where the charge measurement has been optimized through Monte Carlo simulations. I. INTRODUCTION T HE personalized medicine as the heart of healthcare priorities of the 21 st century requires molecular imag-Manuscript
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https://hal-imt-atlantique.archives-ouvertes.fr/hal-03044155
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Submitted on : Tuesday, December 15, 2020 - 10:22:35 AM
Last modification on : Wednesday, April 27, 2022 - 3:50:23 AM
Long-term archiving on: : Tuesday, March 16, 2021 - 6:10:36 PM

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IMT-ATLANTIQUE | SUBATECH | IN2P3 | UNIV-NANTES | CNRS | INSTITUT-TELECOM | LPC-CLERMONT | SUBATECH-XENON | LS2N | EC-NANTES | UNAM | PRES_CLERMONT | LS2N-SIMS | SUBATECH-SERVICES-TECHNIQUES

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Yajing Xing, Mounir Abaline, Stephane Acounis, Nicolas Beaupere, Jean-Luc Beney, et al.. Direct Measurement of Ionization Charges in Single-phase Liquid Xenon Compton Telescope for 3γ Medical Imaging. 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Oct 2019, Manchester, United Kingdom. ⟨10.1109/NSS/MIC42101.2019.9059808⟩. ⟨hal-03044155⟩

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