Skip to Main content Skip to Navigation
Journal articles

Four-dimensional computed tomography angiography analysis of internal carotid arteries opacification at the skull base to detect delayed cerebral ischemia: a feasibility study

Abstract : Purpose Delayed cerebral ischemia represents a significant cause of poor functional outcome for patients with vasospasm after subarachnoid hemorrhage. We investigated whether delayed cerebral ischemia could be detected by the arterial opacification of internal carotid artery at the level of the skull base. Methods In this exploratory, nested retrospective cohort diagnostic accuracy study, patients with clinical and/or transcranial Doppler suspicion of vasospasm who underwent four-dimensional computed tomography angiography were included. They were split into two groups for the main endpoint analysis, according to the actually adopted morphological (cerebral infarction) and clinical criteria (neurologic deterioration) of delayed cerebral ischemia. Opacification with a temporal resolution of 0.15 s of both internal carotid arteries at the skull base level was obtained through a semi-automated segmentation method based on skeletonization, and analyzed by a wavelet transform (rbio2.2, level 1). The results obtained by k-means clustering were analyzed with regard to the state of delayed cerebral infarction. Results Over ten patients included and analyzed, five patients presented a delayed cerebral ischemia, two of them in both side. The semi-automated processing and analysis clustered two different types of opacification curves. The obtaining of a nonlinear opacification pattern was associated (p < 0.001) with delayed cerebral ischemia. Conclusions The analysis of arterial opacification of internal carotid arteries at skull base by the proposed processing is feasible and leads to cluster two types of opacification that may help to early detect and prevent delayed cerebral ischemia, in particularly when examinations are artifacted by aneurysm treatment materials.
Document type :
Journal articles
Complete list of metadata

https://hal-imt-atlantique.archives-ouvertes.fr/hal-03384426
Contributor : Valérie Burdin Connect in order to contact the contributor
Submitted on : Monday, October 18, 2021 - 10:27:41 PM
Last modification on : Wednesday, November 3, 2021 - 10:01:57 AM

Identifiers

Citation

Julien Ognard, Mourad Cheddad El Aouni, Brieg Dissaux, Raphel Jomaah, Pierre-Yves Rousseau, et al.. Four-dimensional computed tomography angiography analysis of internal carotid arteries opacification at the skull base to detect delayed cerebral ischemia: a feasibility study. International Journal of Computer Assisted Radiology and Surgery, Springer Verlag, 2020, 15 (12), pp.2005-2015. ⟨10.1007/s11548-020-02268-y⟩. ⟨hal-03384426⟩

Share

Metrics

Record views

29