(Eta6-arene) ruthenium(II) complexes and metallo-papain hybrid as Lewis acid catalysts of Diels-Alder reaction in water.

Barisa Talbi (1) , Pierre Haquette (1) , Annie Martel (1) , Frédéric de Montigny (1) , Céline Fosse (2) , Stéphane Cordier (3) , Thierry Roisnel (3) , Gérard Jaouen (1) , Michèle Salmain (1)

1 Laboratoire Charles Friedel
2 Laboratoire de spectrométrie de masse
3 ISCR - Institut des Sciences Chimiques de Rennes

Covalent embedding of a (eta(6)-arene) ruthenium(II) complex into the protein papain gives rise to a metalloenzyme displaying a catalytic efficiency for a Lewis acid-mediated catalysed Diels-Alder reaction enhanced by two orders of magnitude in water.

Keywords: Acids/chemistry; Catalysis; Complexes/chemistry; Crystallography; X-Ray; Kinetics; Molecular Conformation; Papain/chemistry; Ruthenium/chemistry; Water/chemistry

Domains: Coordination chemistry

Barisa Talbi, Pierre Haquette, Annie Martel, Frédéric de Montigny, Céline Fosse, et al.. (Eta6-arene) ruthenium(II) complexes and metallo-papain hybrid as Lewis acid catalysts of Diels-Alder reaction in water.. Dalton Transactions, 2010, 39 (24), pp.5605-7. ⟨10.1039/c001630f⟩. ⟨hal-00738766⟩